CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family Phosphonoacetaldehyde hydrolase

Enzyme Information

3.11.1.1
Phosphonoacetaldehyde hydrolase.
based on mapping to UniProt O31156
Phosphonoacetaldehyde + H(2)O = acetaldehyde + phosphate.
-!- This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. -!- The mechanism is similar to that used by EC 4.1.2.13 to break a C-C bond.

UniProtKB Entries (1)

O31156
PHNX_BACCE
Bacillus cereus
Phosphonoacetaldehyde hydrolase

PDB Structure

PDB 2IOF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.
Lahiri, S.D., Zhang, G., Dunaway-Mariano, D., Allen, K.N.
Bioorg.Chem.