CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Wee1-like protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P30291
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P30291
WEE1_HUMAN
Homo sapiens
Wee1-like protein kinase

PDB Structure

PDB 2IO6
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Smaill, J.B., Baker, E.N., Booth, R.J., Bridges, A.J., Dickson, J.M., Dobrusin, E.M., Ivanovic, I., Kraker, A.J., Lee, H.H., Lunney, E.A., Ortwine, D.F., Palmer, B.D., Quin, J., Squire, C.J., Thompson, A.M., Denny, W.A.
Eur.J.Med.Chem.