CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.10 | Thrombin, subunit H |
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2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Genome polyprotein |
Enzyme Information
2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt P03303
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
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3.4.22.28 |
Picornain 3C.
based on mapping to UniProt P03303
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
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3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P03303
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
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3.4.22.29 |
Picornain 2A.
based on mapping to UniProt P03303
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
-!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
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UniProtKB Entries (1)
P03303 |
POLG_HRV14
Rhinovirus B14
Genome polyprotein
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PDB Structure
PDB | 2IN2 |
External Links | |
Method | SOLUTION NMR |
Organism | Escherichia |
Primary Citation |
NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison.
Biochemistry
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