CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloproteases ("zincins"), catalytic domain like
Functional Family

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A

PDB Structure

PDB 2IMC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility.
Silvaggi, N.R., Boldt, G.E., Hixon, M.S., Kennedy, J.P., Tzipori, S., Janda, K.D., Allen, K.N.
Chem.Biol.