CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family

Enzyme Information

2.7.4.22
UMP kinase.
based on mapping to UniProt O28237
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.

UniProtKB Entries (1)

O28237
PYRH_ARCFU
Archaeoglobus fulgidus DSM 4304
Uridylate kinase

PDB Structure

PDB 2IJ9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Uridylate Kinase from Archaeoglobus Fulgidus
Patskovsky, Y., Chen, R., Keefe, L.J., Sauder, J.M., Dickey, M., Adams, J.M., Ozyurt, S., Wasserman, S.R., Burley, S.K., Almo, S.C.
To be Published