CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Inhibitor
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04629
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P01138
NGF_HUMAN
Homo sapiens
Beta-nerve growth factor

PDB Structure

PDB 2IFG
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H., Garcia, K.C.
Neuron