CATH Classification

Domain Context

CATH Clusters

Superfamily 7,8-dihydroneopterin aldolase (MptD)
Functional Family

Enzyme Information

4.1.2.25
Dihydroneopterin aldolase.
based on mapping to UniProt Q8TX89
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.
-!- The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. -!- The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8). -!- The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81. -!- The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.

UniProtKB Entries (1)

Q8TX89
MPTD_METKA
Methanopyrus kandleri AV19
Dihydroneopterin aldolase

PDB Structure

PDB 2IEC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of uncharacterized conserved archael protein from Methanopyrus kandleri
Bonanno, J.B., Ramagopal, U.A., Dickey, M., Bain, K.T., Powell, A., Ozyurt, S., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C.
TO BE PUBLISHED