CATH Classification

Domain Context

CATH Clusters

Superfamily Glycine N-methyltransferase, chain A, domain 1
Functional Family Glycine N-methyltransferase

Enzyme Information

2.1.1.20
Glycine N-methyltransferase.
based on mapping to UniProt P13255
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.

UniProtKB Entries (1)

P13255
GNMT_RAT
Rattus norvegicus
Glycine N-methyltransferase

PDB Structure

PDB 2IDK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.
Luka, Z., Pakhomova, S., Loukachevitch, L.V., Egli, M., Newcomer, M.E., Wagner, C.
J.Biol.Chem.