CATH Classification

Domain Context

CATH Clusters

Superfamily UbiD C-terminal domain-like
Functional Family 3-octaprenyl-4-hydroxybenzoate carboxy-lyase

Enzyme Information

4.1.1.98
4-hydroxy-3-polyprenylbenzoate decarboxylase.
based on mapping to UniProt P0AAB4
A 4-hydroxy-3-polyprenylbenzoate = a 2-polyprenylphenol + CO(2).
-!- The enzyme catalyzes a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. -!- The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. -!- It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129.

UniProtKB Entries (1)

P0AAB4
UBID_ECOLI
Escherichia coli K-12
3-octaprenyl-4-hydroxybenzoate carboxy-lyase

PDB Structure

PDB 2IDB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of 3-octaprenyl-4-hydroxybenzoate decarboxylase (UbiD) from Escherichia coli, Northeast Structural Genomics Target ER459.
Zhou, W., Forouhar, F., Seetharaman, J., Fang, Y., Xiao, R., Cunningham, K., Ma, L.-C., Chen, C.X., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
TO BE PUBLISHED