CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Proprotein convertase subtilisin/kexin type 7

Enzyme Information

3.4.21.61
Kexin.
based on mapping to UniProt P13134
Cleavage of -Lys-Arg-|-Xaa- and -Arg-Arg-|-Xaa- bonds to process yeast alpha-factor pheromone and killer toxin precursors.
-!- Calcium activated. -!- Inhibited by p-mercuribenzoate. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.22.23.

UniProtKB Entries (1)

P13134
KEX2_YEAST
Saccharomyces cerevisiae S288C
Kexin

PDB Structure

PDB 2ID4
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.
Wheatley, J.L., Holyoak, T.
Proc.Natl.Acad.Sci.Usa