CATH Domain 2icaA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.410	von Willebrand factor, type A domain

Domain Context

CATH Clusters

Superfamily	von Willebrand factor, type A domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

ITAL_HUMAN

Homo sapiens

Integrin alpha-L

PDB Structure

PDB	2ICA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)-A Small Molecule Antagonist Leukocyte Function Associated Antigen-1. Potin, D., Launay, M., Monatlik, F., Malabre, P., Fabreguettes, M., Fouquet, A., Maillet, M., Nicolai, E., Dorgeret, L., Chevallier, F., Besse, D., Dufort, M., Caussade, F., Ahmad, S.Z., Stetsko, D.K., Skala, S., Davis, P.M., Balimane, P., Patel, K., Yang, Z., Marathe, P., Postelneck, J., Townsend, R.M., Goldfarb, V., Sheriff, S., Einspahr, H., Kish, K., Malley, M.F., Dimarco, J.D., Gougoutas, J.Z., Kadiyala, P., Cheney, D.L., Tejwani, R.W., Murphy, D.K., McIntyre, K.W., Yang, X., Chao, S., Leith, L., Xiao, Z., Mathur, A., Chen, B.C., Wu, D.R., Traeger, S.C., McKinnon, M., Barrish, J.C., Robl, J.A., Iwanowicz, E.J., Suchard, S.J., Dhar, T.G. J.Med.Chem.