CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P67775
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (2)

Q76MZ3
2AAA_MOUSE
Mus musculus
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
P67775
PP2AA_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PDB Structure

PDB 2IAE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Cho, U.S., Xu, W.
Nature