CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

Q03405
UPAR_HUMAN
Homo sapiens
Urokinase plasminogen activator surface receptor

PDB Structure

PDB 2I9B
External Links
Method X-RAY DIFFRACTION
Organism Drosophila
Primary Citation
Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
Barinka, C., Parry, G., Callahan, J., Shaw, D.E., Kuo, A., Bdeir, K., Cines, D.B., Mazar, A., Lubkowski, J.
J.Mol.Biol.