CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.2350 | Pseudouridine synthase |
|
3.30.2350.10 | Pseudouridine synthase |
Domain Context
CATH Clusters
| Superfamily | Pseudouridine synthase |
| Functional Family | Pseudouridine synthase |
Enzyme Information
| 5.4.99.29 |
23S rRNA pseudouridine(746) synthase.
based on mapping to UniProt P0AA37
23S rRNA uridine(746) = 23S rRNA pseudouridine(746).
-!- RluA is the sole protein responsible for the in vivo formation of 23S RNA pseudouridine(746). -!- The dual-specificity enzyme also catalyzes the formation of uridine(32) in tRNA. -!- Cf. EC 5.4.99.28.
|
| 5.4.99.28 |
tRNA pseudouridine(32) synthase.
based on mapping to UniProt P0AA37
tRNA uridine(32) = tRNA pseudouridine(32).
-!- The dual-specificity enzyme also catalyzes the formation of pseudouridine(746) in 23S rRNA. -!- Cf. EC 5.4.99.29.
|
UniProtKB Entries (1)
| P0AA37 |
RLUA_ECOLI
Escherichia coli K-12
Ribosomal large subunit pseudouridine synthase A
|
PDB Structure
| PDB | 2I82 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure
Mol.Cell
|