CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Receptor-type tyrosine-protein phosphatase beta

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P23467
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P23467
PTPRB_HUMAN
Homo sapiens
Receptor-type tyrosine-protein phosphatase beta

PDB Structure

PDB 2I4E
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Evdokimov, A.G., Pokross, M., Walter, R., Mekel, M., Cox, B., Li, C., Bechard, R., Genbauffe, F., Andrews, R., Diven, C., Howard, B., Rastogi, V., Gray, J., Maier, M., Peters, K.G.
Acta Crystallogr.,Sect.D