CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarylacetoacetase, N-terminal domain
Functional Family Fumarylacetoacetase

Enzyme Information

3.7.1.2
Fumarylacetoacetase.
based on mapping to UniProt P35505
4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.
-!- Also acts on other 3,5- and 2,4-dioxo acids.

UniProtKB Entries (1)

P35505
FAAA_MOUSE
Mus musculus
Fumarylacetoacetase

PDB Structure

PDB 2HZY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Bateman, R.L., Ashworth, J., Witte, J.F., Baker, L.J., Bhanumoorthy, P., Timm, D.E., Hurley, T.D., Grompe, M., McClard, R.W.
Biochem.J.