CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.21 | Purple Acid Phosphatase; chain A, domain 2 |
|
3.60.21.10 | Metallo-dependent phosphatases |
Domain Context
CATH Clusters
| Superfamily | 3.60.21.10 |
| Functional Family |
Enzyme Information
| 3.1.4.53 |
3',5'-cyclic-AMP phosphodiesterase.
based on mapping to UniProt P9WP65
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.
|
UniProtKB Entries (1)
| P9WP65 |
CPDA_MYCTU
Mycobacterium tuberculosis H37Rv
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
|
PDB Structure
| PDB | 2HYP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
J.Mol.Biol.
|