CATH Domain 2hwgA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.274	Enzyme I; Chain A, domain 2
	1.10.274.10	PtsI, HPr-binding domain

Domain Context

CATH Clusters

Superfamily	PtsI, HPr-binding domain
Functional Family	Phosphoenolpyruvate-protein phosphotransferase

Enzyme Information

2.7.3.9

Phosphoenolpyruvate--protein phosphotransferase.

based on mapping to UniProt P08839

Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.

-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.

UniProtKB Entries (1)

P08839

PT1_ECOLI

Escherichia coli K-12

Phosphoenolpyruvate-protein phosphotransferase

PDB Structure

PDB	2HWG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein. Teplyakov, A., Lim, K., Zhu, P.P., Kapadia, G., Chen, C.C., Schwartz, J., Howard, A., Reddy, P.T., Peterkofsky, A., Herzberg, O. Proc.Natl.Acad.Sci.Usa