CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.120.1150
Functional Family Serine/threonine-protein phosphatase 2A activator

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q15257
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q15257
PTPA_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase 2A activator

PDB Structure

PDB 2HV7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and mechanism of the phosphotyrosyl phosphatase activator.
Chao, Y., Xing, Y., Chen, Y., Xu, Y., Lin, Z., Li, Z., Jeffrey, P.D., Stock, J.B., Shi, Y.
Mol.Cell