CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Short-chain dehydrogenase reductase

Enzyme Information

1.1.1.53
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase.
based on mapping to UniProt P19992
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
-!- The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.

UniProtKB Entries (1)

P19992
HSD_STREX
Streptomyces exfoliatus
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

PDB Structure

PDB 2HSD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases.
Ghosh, D., Wawrzak, Z., Weeks, C.M., Duax, W.L., Erman, M.
Structure