CATH Classification

Domain Context

CATH Clusters

Superfamily 2.70.40.10
Functional Family dUTP diphosphatase

Enzyme Information

3.6.1.23
dUTP diphosphatase.
based on mapping to UniProt P06968
dUTP + H(2)O = dUMP + diphosphate.

UniProtKB Entries (1)

P06968
DUT_ECOLI
Escherichia coli K-12
Deoxyuridine 5'-triphosphate nucleotidohydrolase

PDB Structure

PDB 2HRM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Kovari, J., Barabas, O., Varga, B., Bekesi, A., Tolgyesi, F., Fidy, J., Nagy, J., Vertessy, B.G.
Proteins