CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.70 | Distorted Sandwich | |
2.70.40 | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A | |
2.70.40.10 | Deoxyuridine triphosphatase (dUTPase) |
Domain Context
CATH Clusters
Superfamily | 2.70.40.10 |
Functional Family | dUTP diphosphatase |
Enzyme Information
3.6.1.23 |
dUTP diphosphatase.
based on mapping to UniProt P06968
dUTP + H(2)O = dUMP + diphosphate.
|
UniProtKB Entries (1)
P06968 |
DUT_ECOLI
Escherichia coli K-12
Deoxyuridine 5'-triphosphate nucleotidohydrolase
|
PDB Structure
PDB | 2HRM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins
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