CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P14489
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P14489
BLO10_PSEAI
Pseudomonas aeruginosa
Beta-lactamase OXA-10

PDB Structure

PDB 2HP6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.
Baurin, S., Vercheval, L., Bouillenne, F., Falzone, C., Brans, A., Jacquamet, L., Ferrer, J.L., Sauvage, E., Dehareng, D., Frere, J.M., Charlier, P., Galleni, M., Kerff, F.
Biochemistry