CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Trypsin alpha

Enzyme Information

3.4.21.49
Hypodermin C.
based on mapping to UniProt P08897
Hydrolysis of proteins including native collagen at Xaa-|-Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment.
-!- Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08897
COGS_HYPLI
Hypoderma lineatum
Collagenase

PDB Structure

PDB 2HLC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
1.8 A structure of Hypoderma lineatum collagenase: a member of the serine proteinase family.
Broutin, I., Arnoux, B., Riche, C., Lecroisey, A., Keil, B., Pascard, C., Ducruix, A.
Acta Crystallogr.,Sect.D