CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family Poly(A) polymerase alpha, putative

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P29468
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P29468
PAP_YEAST
Saccharomyces cerevisiae S288C
Poly(A) polymerase

PDB Structure

PDB 2HHP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase.
Balbo, P.B., Toth, J., Bohm, A.
J.Mol.Biol.