CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase G

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P30414
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P30414
NKTR_HUMAN
Homo sapiens
NK-tumor recognition protein

PDB Structure

PDB 2HE9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis, T.L., Walker, J.R., Campagna-Slater, V., Finerty, P.J., Paramanathan, R., Bernstein, G., MacKenzie, F., Tempel, W., Ouyang, H., Lee, W.H., Eisenmesser, E.Z., Dhe-Paganon, S.
PLoS Biol.