CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family

Enzyme Information

2.3.3.10
Hydroxymethylglutaryl-CoA synthase.
based on mapping to UniProt Q9FD71
Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
-!- Formerly EC 4.1.3.5.

UniProtKB Entries (1)

Q9FD71
HMGCS_ENTFL
Enterococcus faecalis
Hydroxymethylglutaryl-CoA synthase

PDB Structure

PDB 2HDB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Steussy, C.N., Robison, A.D., Tetrick, A.M., Knight, J.T., Rodwell, V.W., Stauffacher, C.V., Sutherlin, A.L.
Biochemistry