CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-helical ferredoxin
Functional Family Succinate dehydrogenase iron-sulfur subunit

Enzyme Information
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT2
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC

UniProtKB Entries (1)

Gallus gallus
Succinate dehydrogenase cytochrome b, large subunit

PDB Structure

PDB 2H88
External Links
Primary Citation
Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the
Huang, L.S., Shen, J.T., Wang, A.C., Berry, E.A.