CATH Domain 2h84A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.47	Peroxisomal Thiolase; Chain A, domain 1
	3.40.47.10	Thiolase/Chalcone synthase

Domain Context

CATH Clusters

Superfamily	3.40.47.10
Functional Family	Chalcone synthase 2

Enzyme Information

2.3.1.74	Chalcone synthase. based on mapping to UniProt Q55E72 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2). -!- The enzyme catalyzes the first committed step in the biosynthesis of flavonoids. -!- It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
2.3.1.-	Transferring groups other than amino-acyl groups. based on mapping to UniProt Q55E72

UniProtKB Entries (1)

PKS1_DICDI

Dictyostelium discoideum

Probable polyketide synthase 1

PDB Structure

PDB	2H84
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Austin, M.B., Saito, T., Bowman, M.E., Haydock, S., Kato, A., Moore, B.S., Kay, R.R., Noel, J.P. Nat.Chem.Biol.