CATH Domain 2h62D00
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13705
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 126.96.36.199.
UniProtKB Entries (1)
Bone morphogenetic protein 2
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.