CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.60 CD59
Homologous Superfamily CD59

Domain Context

CATH Clusters

Superfamily CD59
Functional Family

Enzyme Information
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13705
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Bone morphogenetic protein 2

PDB Structure

PDB 2H62
External Links
Organism Escherichia
Primary Citation
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., Mueller, T.D.
Bmc Struct.Biol.