CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.12
Alpha-lytic endopeptidase.
based on mapping to UniProt P00778
Preferential cleavage: Ala-|-Xaa, Val-|-Xaa in bacterial cell walls, elastin and other proteins.
-!- Belongs to peptidase family S1E.

UniProtKB Entries (1)

P00778
PRLA_LYSEN
Lysobacter enzymogenes
Alpha-lytic protease

PDB Structure

PDB 2H5C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
Fuhrmann, C.N., Daugherty, M.D., Agard, D.A.
J.Am.Chem.Soc.