CATH Domain 2h40A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB	2H40
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development Wang, H., Liu, Y., Huai, Q., Cai, J., Zoraghi, R., Francis, S.H., Corbin, J.D., Robinson, H., Xin, Z., Lin, G., Ke, H. J.Biol.Chem.