CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt P62617
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P62617
ISPF_ECOLI
Escherichia coli K-12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 2GZL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Fluorescent Inhibitors for Ispf, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy.
Crane, C.M., Kaiser, J., Ramsden, N.L., Lauw, S., Rohdich, F., Eisenreich, W., Hunter, W.N., Bacher, A., Diederich, F.
Angew.Chem.Int.Ed.Engl.