CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase Mu 1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P28161
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P28161
GSTM2_HUMAN
Homo sapiens
Glutathione S-transferase Mu 2

PDB Structure

PDB 2GTU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The enhanced affinity for thiolate anion and activation of enzyme-bound glutathione is governed by an arginine residue of human Mu class glutathione S-transferases.
Patskovsky, Y.V., Patskovska, L.N., Listowsky, I.
J.Biol.Chem.