CATH Classification

Domain Context

CATH Clusters

Superfamily Dehydroquinate synthase-like - alpha domain
Functional Family

Enzyme Information

4.2.3.124
2-deoxy-scyllo-inosose synthase.
based on mapping to UniProt Q9S5E2
D-glucose-6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate.
-!- Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. -!- Requires an NAD(+) cofactor, which is transiently reduced during the reaction. -!- The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex.

UniProtKB Entries (1)

Q9S5E2
DOIS_BACCI
Bacillus circulans
2-deoxy-scyllo-inosose synthase

PDB Structure

PDB 2GRU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+
Nango, E., Kumasaka, T., Hirayama, T., Tanaka, N., Eguchi, T.
Proteins