CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Pyrroline-5-carboxylate reductase 1

Enzyme Information

1.5.1.2
Pyrroline-5-carboxylate reductase.
based on mapping to UniProt P32322
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

UniProtKB Entries (1)

P32322
P5CR1_HUMAN
Homo sapiens
Pyrroline-5-carboxylate reductase 1, mitochondrial

PDB Structure

PDB 2GR9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human pyrroline-5-carboxylate reductase
Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z.
J.Mol.Biol.