CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.60 CD59
Homologous Superfamily 2.10.60.10 CD59

Domain Context

CATH Clusters

Superfamily CD59
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36894
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

P27038
AVR2A_MOUSE
Mus musculus
Activin receptor type-2A
P12643
BMP2_HUMAN
Homo sapiens
Bone morphogenetic protein 2

PDB Structure

PDB 2GOO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the ternary signaling complex of a TGF-beta superfamily member.
Allendorph, G.P., Vale, W.W., Choe, S.
Proc.Natl.Acad.Sci.Usa