CATH Classification

Domain Context

CATH Clusters

Superfamily DNA mismatch repair MutH/Restriction endonuclease, type II
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P17743
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P17743
T2C2_HAEIF
Haemophilus influenzae
Type-2 restriction enzyme HincII

PDB Structure

PDB 2GIE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
Joshi, H.K., Etzkorn, C., Chatwell, L., Bitinaite, J., Horton, N.C.
J.Biol.Chem.