CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14757
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757
CHK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk1

PDB Structure

PDB 2GDO
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Ni, Z.J., Barsanti, P., Brammeier, N., Diebes, A., Poon, D.J., Ng, S., Pecchi, S., Pfister, K., Renhowe, P.A., Ramurthy, S., Wagman, A.S., Bussiere, D.E., Le, V., Zhou, Y., Jansen, J.M., Ma, S., Gesner, T.G.
Bioorg.Med.Chem.Lett.