CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Inactive serine protease 45

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt P20231
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231
TRYB2_HUMAN
Homo sapiens
Tryptase beta-2

PDB Structure

PDB 2GDD
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Human beta II tryptase with inhibitor CRA-27592
Somoza, J.R.
To be Published