CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Glyoxylate reductase/hydroxypyruvate reductase b |
Enzyme Information
| 1.1.1.79 |
Glyoxylate reductase (NADP(+)).
based on mapping to UniProt Q9UBQ7
Glycolate + NADP(+) = glyoxylate + NADPH.
-!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).
|
| 1.1.1.81 |
Hydroxypyruvate reductase.
based on mapping to UniProt Q9UBQ7
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
|
UniProtKB Entries (1)
| Q9UBQ7 |
GRHPR_HUMAN
Homo sapiens
Glyoxylate reductase/hydroxypyruvate reductase
|
PDB Structure
| PDB | 2GCG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase
J.Mol.Biol.
|