CATH Classification

Domain Context

CATH Clusters

Superfamily formyl-coa transferase, domain 3
Functional Family

Enzyme Information

2.8.3.16
Formyl-CoA transferase.
based on mapping to UniProt O06543
Formyl-CoA + oxalate = formate + oxalyl-CoA.
-!- The enzyme from Oxalobacter formigenes can also catalyze the transfer of CoA from formyl-CoA to succinate.
5.1.99.4
Alpha-methylacyl-CoA racemase.
based on mapping to UniProt O06543
(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.
-!- Alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C(10) are substrates. -!- Also active toward some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. -!- Not active toward free acids.

UniProtKB Entries (1)

O06543
O06543_MYCTU
Mycobacterium tuberculosis H37Rv
Carnitine dehydratase

PDB Structure

PDB 2GCE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface
Bhaumik, P., Schmitz, W., Hassinen, A., Hiltunen, J.K., Conzelmann, E., Wierenga, R.K.
J.Mol.Biol.