CATH Domain 2gasB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Bifunctional pinoresinol-lariciresinol reductase 1

Enzyme Information

1.3.1.45

2'-hydroxyisoflavone reductase.

based on mapping to UniProt P52575

Vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH.

-!- In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. -!- Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.

UniProtKB Entries (1)

P52575

IFR_MEDSA

Medicago sativa

Isoflavone reductase

PDB Structure

PDB	2GAS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Isoflavone Reductase from Alfalfa (Medicago sativa L.) Wang, X., He, X., Lin, J., Shao, H., Chang, Z., Dixon, R.A. J.Mol.Biol.