CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 3
Functional Family

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt P46799
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P46799
TOP1_THEMA
Thermotoga maritima MSB8
DNA topoisomerase 1

PDB Structure

PDB 2GAI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima
Hansen, G., Harrenga, A., Wieland, B., Schomburg, D., Reinemer, P.
J.Mol.Biol.