CATH Classification

Domain Context

CATH Clusters

Superfamily Hypothetical oxidoreductase yiak; domain 2
Functional Family

Enzyme Information

1.1.1.237
Hydroxyphenylpyruvate reductase.
based on mapping to UniProt P30178
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)(+) = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H. (2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)(+) = 3-(3,4- dihydroxyphenyl)pyruvate + NAD(P)H.
-!- The enzyme participates in the biosynthesis of rosmarinic acid. -!- It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
1.1.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P30178

UniProtKB Entries (1)

P30178
HCXB_ECOLI
Escherichia coli K-12
Hydroxycarboxylate dehydrogenase B

PDB Structure

PDB 2G8Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of a putative malate/lactate dehydrogenase from E. coli.
Cuff, M.E., Skarina, T., Edwards, A., Savchenko, A., Cymborowski, M., Minor, W., Joachimiak, A.
To be Published