CATH Classification

Domain Context

CATH Clusters

Functional Family

Enzyme Information
Peptidylprolyl isomerase.
based on mapping to UniProt Q15257
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Homo sapiens
Serine/threonine-protein phosphatase 2A activator

PDB Structure

PDB 2G62
External Links
Organism Escherichia
Primary Citation
The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
Magnusdottir, A., Stenmark, P., Flodin, S., Nyman, T., Hammarstrom, M., Ehn, M., Bakali H, M.A., Berglund, H., Nordlund, P.