CATH Classification

Domain Context

CATH Clusters

Superfamily Pyruvate kinase, C-terminal domain
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P11974
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P11974
KPYM_RABIT
Oryctolagus cuniculus
Pyruvate kinase PKM

PDB Structure

PDB 2G50
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase.
Williams, R., Holyoak, T., McDonald, G., Gui, C., Fenton, A.W.
Biochemistry