CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (2)

P35804
BLIP_STRCL
Streptomyces clavuligerus
Beta-lactamase inhibitory protein
P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 2G2W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface.
Reynolds, K.A., Thomson, J.M., Corbett, K.D., Bethel, C.R., Berger, J.M., Kirsch, J.F., Bonomo, R.A., Handel, T.M.
J.Biol.Chem.