CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1500 | oxygen-dependent coproporphyrinogen oxidase |
|
3.40.1500.20 |
Domain Context
CATH Clusters
| Superfamily | 3.40.1500.20 |
| Functional Family |
Enzyme Information
| 1.3.7.5 |
Phycocyanobilin:ferredoxin oxidoreductase.
based on mapping to UniProt Q93TN0
(3Z)-phycocyanobilin + 4 oxidized ferredoxin = biliverdin IX-alpha + 4 reduced ferredoxin.
-!- Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings). -!- Reaction proceeds via an isolatable 2-electron intermediate, 18(1),18(2)-dihydrobiliverdin. -!- Flavodoxins can be used instead of ferredoxin. -!- The direct conversion of biliverdin IX-alpha (BV) to (3Z)- phycocyanobilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
|
UniProtKB Entries (1)
| Q93TN0 |
PCYA_NOSS1
Nostoc sp. PCC 7120
Phycocyanobilin:ferredoxin oxidoreductase
|
PDB Structure
| PDB | 2G18 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Insight into the radical mechanism of phycocyanobilin-ferredoxin oxidoreductase (PcyA) revealed by X-ray crystallography and biochemical measurements.
Biochemistry
|