CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase gamma 1

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt P20231
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231
TRYB2_HUMAN
Homo sapiens
Tryptase beta-2

PDB Structure

PDB 2FXR
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Structure-guided design of Peptide-based tryptase inhibitors.
McGrath, M.E., Sprengeler, P.A., Hirschbein, B., Somoza, J.R., Lehoux, I., Janc, J.W., Gjerstad, E., Graupe, M., Estiarte, A., Venkataramani, C., Liu, Y., Yee, R., Ho, J.D., Green, M.J., Lee, C.-S., Liu, L., Tai, V., Spencer, J., Sperandio, D., Katz, B.A.
Biochemistry