CATH Domain 2fxrA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase beta-2

Enzyme Information

3.4.21.59

Tryptase.

based on mapping to UniProt P20231

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.

-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231

TRYB2_HUMAN

Homo sapiens

Tryptase beta-2

PDB Structure

PDB	2FXR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	Structure-guided design of Peptide-based tryptase inhibitors. McGrath, M.E., Sprengeler, P.A., Hirschbein, B., Somoza, J.R., Lehoux, I., Janc, J.W., Gjerstad, E., Graupe, M., Estiarte, A., Venkataramani, C., Liu, Y., Yee, R., Ho, J.D., Green, M.J., Lee, C.-S., Liu, L., Tai, V., Spencer, J., Sperandio, D., Katz, B.A. Biochemistry